DTW, my home airport
SAN on AS
AMS on KL (I yearn for that blue plane over my backyard like my childhood summers)
PDX at a more reasonable time than the evening from DL
DTW-EYW (finally, a direct option to Florida that isn't full of kids)
DTW-ANC resumption
DTW-KIX
DTW-HKG
DTW-STR on DL (this one seems to make a lot of sense in my head)
DTW-DUS
DTW-DUB
DTW-MAN on DL / VS
DTW-IST on TK
DTW-MAD - I know NW announced this many years ago, but fizzed out.
and since I was an exchange student here, I'll include CTS (Sapporo / New Chitose). It's a small airport, but Hokkaido holds a special place in my heart.
AY HEL-CTS on an A333 (Rumored to happen. We shall see)
KL AMS-CTS (don't know why. I just think it sounds cool - 789 3x weekly)
DL SEA-CTS 3x weekly 763 would be a dream come true for me. I don't mind the idea of going via NRT or ICN on KE, but I love the idea of having a connection to the US Mainland from Hokkaido.